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IGF-1 receptor inhibitor

Potent inhibitor of insulin-like growth factor I receptor (IGF-IR) signalling and breast cancer cell growth in culture and in vivo.

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Alternative Name	IGF-IR Inhibitor, N-(5-Chloro-2-methoxyphenyl)-N’-(2-methyl-4-quinolinyl)urea
Appearance	Off-white solid.
CAS	196868-63-0
Couple Target	IGF receptor
Couple Type	Inhibitor
Formula	C₁₈H₁₆ClN₃O₂
MW	341.8
Purity	≥98% (HPLC (UV))
Solubility	Soluble in DMSO (10mg/ml) or methanol (7mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2: Slocum, E., Craig, A., et al.; Breast Cancer Res. 21, 56 (2019), Abstract
Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer: Takabatake, Y., Oxvig, C., et al.; EMBO Mol. Med. 8, 388 (2016), Abstract
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth: K.L. Gable, et al.; Mol. Cancer Ther. 5, 1079 (2006), Abstract

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