pppG(2′,5′)pA

In pppG(2′,5′)pA a 5′-GTP unit is connected with a 5′-AMP unit via a 2′ → 5′ linkage to form a linear dinucleotide. pppG(2′,5′)pA is considered to be the linear catalytic intermediate in the enzymatic production of 2′,3′-cGAMP (aka c[G(2′,5′)pA(3′,5′)p], Prod. No. BLG-C161) by the mammalian innate immune DNA sensor cGAMP synthase (cGAS).

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