PPACK

BML-PI117

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Thrombin inhibitor

Potent irreversible thrombin inhibitor. Inhibits thrombin activation of progelatinase A. Pretreatment with PPACK inhibits thrombin-induced cerebral thromboembolism in vivo.

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Product Details

Alternative Name	D-Phe-Pro-Arg-CMK
Appearance	White to off-white solid.
CAS	71142-71-7
Formula	C₂₁H₃₁ClN₆O₃
MW	451.0
Purity	≥90% (HPLC)
Sequence	D-Phe-Pro-Arg-chloromethylketone
Solubility	Soluble in water.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia: D. Li, et al.; Mol. Med. Rep. 23, 449 (2021), Abstract — Full Text
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin: L.C. Burzynski, et al.; Immunity 50, 1033 (2019), Abstract
Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways: I. Lee-Rivera, et al.; Exp. Eye Res. 139, 81 (2015), Application(s): Thrombin-induced proliferation, Abstract
Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis: S. Zucker, et al.; J. Biol. Chem. 270, 23730 (1995), Abstract
Markers of coagulation and fibrinolysis in blood drawn into citrate with and without D-Phe-Pro-Arg-Chloromethylketone (PPACK): H.B. Rahr, et al.; Thromb. Res. 73, 279 (1994), Abstract
Thrombin inhibitors and anti-coagulants on thrombin-induced embolisation in rabbit cranial vasculature: J.T. Liu, et al.; Eur. J. Pharmacol. 264, 183 (1994), Abstract
D-Phe-Pro-ArgCH2C1-A selective affinity label for thrombin: C. Kettner & E. Shaw; Thromb. Res. 14, 969 (1979), Abstract

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PPACK

BML-PI117

Product Details

Handling & Storage

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