PP2

BML-EI297

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Src kinase inhibitor

A potent and selective inhibitor of the Src family tyrosine kinases. Inhibits Lck (IC₅₀=4 nM), Fyn (IC₅₀=5 nM), and Hck (IC₅₀=5 nM). It displays weaker inhibition of EGFR (IC₅₀=480 nM) and no inhibition of ZAP-70 (IC₅₀ 100 µM) and JAK2 (IC₅₀50 µM). PP2 is a useful tool for probing the involvement of Src family tyrosine kinases in cellular signaling.

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Product Details

Alternative Name	AG1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Appearance	Off-white solid.
CAS	172889-27-9
Couple Target	Src kinase
Couple Type	Inhibitor
Formula	C₁₅H₁₆CIN₅
MW	301.8
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Shear stress induces monocyte/macrophage-mediated inflammation by upregulating cell-surface expression of heat shock proteins: H. Son, et al.; Biomed. Pharmacother. 161, 114566 (2023), Abstract
CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells: W. Deng, et al.; J. Transl. Med. 14, 32 (2016), Application(s): Cell culture, Abstract — Full Text
Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) are Proximal and Essential for Phosphatidylinositol-3 Kinase (PI3K) Activation in Natural Killer (NK) Cell-Mediated Direct Cytotoxicity Against C. neoformans: R.F. Xiang, et al.; J. Biol. Chem. 291, 6912 (2016), Application(s): Cell culture, Abstract — Full Text
Gαs proteins Activate p72 Syk and p60-c-Src Tyrosine Kinases to Mediate Sickle Red Blood Cell Adhesion to Endothelium via LW-αvβ3 and CD44-CD44 Interactions: E. Chiou, et al.; Int. J. Biochem. Cell. Biol. 65, 40 (2015), Application(s): Cell Culture, Abstract
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract
Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology: W. Tong, et al.; PLoS One 10, e0134255 (2015), Application(s): Pharmacological inhibition , Abstract — Full Text
Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis: Kindrachuk, J., Ork, B., et al.; Antimicrob. Agents Chemother. 59, 1088 (2015), Abstract
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP: Chiodi, V., Mallozzi, C., et al.; Neuropsychopharmacology 39, 569 (2014), Abstract
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase: Bacchiocchi, R., Baldanzi, G., et al.; Blood 106, 2175 (2005), Abstract
Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2): F. Carlomagno et al.; J. Clin. Endocrinol. Metab. 88, 1897 (2003), Abstract

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PP2

BML-EI297

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Handling & Storage

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