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Ponasterone A

ALX-370-014

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Ecdysteroid

A member of the ecdysteroid family. Analog of ecdysone with similar properties to muristerone A. It is a functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Results show that ponasterone A was able to induce expression of β-galactosidase to levels similar to those obtained with muristerone A induction. Potent compound for ecdysteroid activity; EC₅₀= 0.07 µM.

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Product Details

Alternative Name	25-Deoxy-20-hydroxyecdysone, 25-Deoxyecdysterone, 2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one
Appearance	White to off-white powder.
CAS	13408-56-5
Formula	C₂₇H₄₄O₆
Identity	Identity determined by NMR.
MI	14: 7588
MW	464.6
Purity	≥95% (HPLC)
Solubility	Soluble in acetic acid, 100% ethanol, methanol or DMSO; insoluble in water.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg (2µmol). Gently mix to dissolve the product (5 to 10 min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Protective role ofPtendownregulation in Huntington’s Disease models: Nisha, Thapliyal, D., et al.; bioRxiv , (2024)
Reconfigurable Hybrid interface for molecular marker diagnostics and in-situ reporting: K. Ehrhardt, et al.; Biosens. Bioelectron. 74, 744 (2015), Application(s): Cell Culture, Abstract
Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1: M. Cui, et al.; J. Biol. Chem. 285, 11740 (2010), Abstract — Full Text
Development of an in vitro Reporter Gene Assay for Screening the Ecdysone Receptor Agonists in Mysid Crustacean: M. Hirano, et al.; Interdisciplinary Studies on Environmental Chemistry 4, 141 (2010), (Book chapter), Full Text
Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth: L. Nardinocchi, et al.; Biochim. Biophys. Acta 1793, 368 (2009), Abstract
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations: Di Stefano, V., Mattiussi, M., et al.; FEBS Lett. 579, 5473 (2005), Abstract
Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells: Y.Y. Xiao, et al.; Int. J. Biochem. Cell. Biol. 35, 79 (2003), Abstract
Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002), Abstract
Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000), Abstract
Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992), Abstract

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Ponasterone A

ALX-370-014

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Handling & Storage

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