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Pomalidomide is a thalidomide derivative and a potent TNF-α inhibitor (IC50 = 13 nM). It also potently inhibits IL-2 (EC50 = 8 nM). It binds cereblon and inhibits its ubiquitination. Pomalidomide exhibits antiproliferative effects in a Namalwa lymphoma cell line and is antiangiogenic.
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