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Polymyxin B . sulfate

ALX-380-040

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PKC inhibitor

Antibiotic. Inhibitor of protein kinase C (PKC). Breaks the bacterial membrane by incorporating into the phospholipid of the outer membrane and activating phospholipase.

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Product Details

Appearance	White to off-white powder.
CAS	1405-20-5
Couple Target	Phospholipase, PKC
Couple Type	Activator, Inhibitor
MI	14: 7573
Purity	≥80% (HPLC) (sum of polymyxins B1, B2, B3, B1-I)
Purity Detail	Mixture of Polymyxin B1, B2, B3 and B1-I.
RTECS	TR1150000
Solubility	Soluble in water (50mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Immune activation of vaginal human Langerhans cells increases susceptibility to HIV-1 infection: N.H.V. Teijlingen, et al.; Sci. Rep. 13, 3283 (2023), Abstract
The effect of temperature and heat shock protein 72 on the ex vivo acute inflammatory response in monocytes: S.P. Hoekstra, et al.; Cell Stress Chaperones 24, 461 (2019), Application(s): experimental treatement- human male blood, Abstract
Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule: D. Ferrari, et al.; Br. J. Pharmacol. 150, 445 (2007), Abstract
Polymyxin antibiotics for gram-negative infections: T. M. Arnold, et al.; Am. J. Health Syst. Pharm. 64, 819 (2007), Review, Abstract
Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion: B. Valentinis, et al.; J. Biol. Chem. 280, 14264 (2005), Abstract
Gap junctional conductance tunes phase difference of cholecystokinin evoked calcium oscillations in pairs of pancreatic acinar cells: A. Ngezahayo & H.A. Kolb; Pfluegers Arch. 422, 413 (1993), Abstract
Inhibitors such as staurosporine, H-7 or polymyxin B cannot be used in skeletal muscle to prove the role of protein kinase C on insulin action: A. Guma, et al.; Biosci. Rep. 12, 413 (1992), Abstract
Volume-regulatory Cl- channel currents in cultured human epithelial cells: M. Kubo & Y. Okada; J. Physiol. 456, 351 (1992), Abstract
Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B & cardiotoxin. Differential inhibition of PKC, CaMKII & synaptosomal membrane Na,K-ATPase & Na+ pump & differentiation of HL60 cells.: R.L. Raynor, et al.; J. Biol. Chem. 266, 2753 (1991), Abstract — Full Text
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine: C. Schächtele, et al.; BBRC 151, 542 (1988), Abstract

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Polymyxin B . sulfate

ALX-380-040

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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