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Polygodial

BML-CA242

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TRPA1 activator

Produced from the bark of Drymis winteri. Naturally occurring drimane sesquiterpene found in water pepper (Polygonum hydropiper) which has been used in folk medicine for a variety of indications. Potent and selective activator of TRPA1 (EC₅₀= 400nM).

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Product Details

Alternative Name	(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Appearance	White to off white solid or waxy solid.
CAS	6754-20-7
Couple Target	TRP channel
Couple Type	Activator
Formula	C₁₅H₂₂O₂
MW	234.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml).
Source	Isolated from Polygonum hydropiper.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Metamorphosis of the invasive ascidian Ciona savignyi: environmental variables and chemical exposure: P.L. Cahill, et al.; PeerJ. 4, e1739 (2016), Application(s): Cell culture, Abstract — Full Text
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents: J. Escalera, et al.; J. Biol. Chem. 283, 24136 (2008), Abstract
Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation: A. Malheiros, et al.; J. Pharm. Pharm. Sci. 8, 335 (2008), Abstract
Inhibition of the mitochondrial ATP synthesis by polygodial, a naturally occurring dialdehyde unsaturated sesquiterpene: M. V. Castelli, et al.; Biochem. Pharmacol. 70, 82 (2005), Abstract
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats: E. Andre, et al.; Neuropharmacology. 46, 590 (2004), Abstract

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Polygodial

BML-CA242

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