Polycomb 2 polyclonal antibody

Polycomb 2 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. Polycomb 2 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. Polycomb 2 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. Polycomb 2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.