Polyclonal Antibody to MTA2

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 [1], p53R2 [2], p53AIP1 [3], Noxa [4], PIDD [5] and PID(MTA2) [6], were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD,NuRD) complex [6-9]. The PID(MTA2) modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID(MTA2) represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis [6]. PID(MTA2) is ubiquitously expressed in human tissues [8].