Polyclonal Antibody to IL-21 (human) (IN)

A novel cytokine was recently identified in human and mouse and designated IL-21 [1], which has significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family [1,2]. IL-21R forms a complex with the common cytokine receptor γ chain, γ_c, and mediates IL-21 signaling [3,4]. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.