Polyclonal Antibody to GFRα-3 (IN)

Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin [1]. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ [2]. Following the findings of GFRα-1 and -2, a novel receptor in GFRa family was identified from human and mouse and designated GFRα-3 [3-7]. GFRα-3 binds persephin, thus, persephin, GFRα-3 and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.