Polyclonal Antibody to FLIP (NT)

Deregulation of apoptosis is related to a variety of diseases. Apoptosis can be induced by a family of death receptors within the TNF-receptor family and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively [1-3]. The human FLIP was also termed Casper, I-FLICE, FLAME-1, CASH and CLARP [3-8]. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with the adapter protein FADD and caspase-8 and