Polyclonal Antibody to FLASH (human) (CT)

A novel mammalian CED-4 homolog was recently identified and cloned in mouse [1] and human [2] and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 [1,3]. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity [1,2]. FLASH is widely expressed.