Polyclonal Antibody to F1Aα

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1β [1,2]. F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1 [1,2]. FEM-1/F1Aα is cleaved by CED-3 and caspase [3]. FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1 [3]. Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues [1,2].