Polyclonal Antibody to DcR3 (NT)

Apoptosis is induced by certain cytokines including TNF and Fas ligand (CD95L) of the TNF family through their death domain containing receptors. Several novel members in the TNF-R family including DR3, TRAIL-R1 (DR4), TRAIL-R2 (DR5), and DR6 were discovered and function as death receptors. Two putative decoy receptors, TRAIL-R3 and TRAIL-R4, were identified to compete with TRAIL-R1 and TRAIL-R2 for their ligand TRAIL binding. A novel decoy receptor was discovered and designated DcR3 and TR6, respectively [1,2]. Unlike TRAIL-R3 and TRAIL-R4, TR6 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis [1,2]. TR6 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.