Polyclonal Antibody to CIDE-B (mouse) (CT)

Deregulation of apoptosis is related to many diseases and can also be induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45(ICAD) has been identified as an inhibitor of caspase activated DNase DFF40(CAD). DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified [1]. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45(ICAD) and DFF40(CAD) [1,2]. Expression of CIDE-B induces apoptosis, which is inhibited by DFF45. CIDE-B is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-B is expressed mainly in liver and at lower levels in spleen, kidney, peripheral blood lymphocytes (PBL), and bone marrow [1].