Polyclonal Antibody to CIDE-A (human) (CT)

Deregulation of apoptosis is related to a varity diseases and can also be induced by a family of death receptors within the TNF receptor family. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF40(CAD), which is chaperoned and inhibited by DFF45(ICAD) [1-4]. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were identified [5]. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45(ICAD) and DFF40(CAD) [5,6]. Expression of CIDE-A induces DNA fragmention and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in multiple tissues.