Polyclonal Antibody to CCR5 (human) (NT)

Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were identified as HIV coreceptors [1,2]. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells [3,4]. CCR5 is required for the infection by HIV-1, HIV-2 and SIV [1,2]. The β-chemokines RANTES, MIP-1α and MIP-1β are the ligands for CCR5 and prevent infection by M-tropic HIV-1 [3-5]. CXC5 associates with the surface CD4-gp 120 of HIV complex and leads to membrane fusion and virus entry of target cells [6,7]. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites [8,9]. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.