Polyclonal Antibody to Bnip3L (human) (IN)

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A BH3 domain containing protein was identified and designated Bnip3L, Bnip3a, and Nix (for Nip3-like Protein X) [1-3]. Bnip3L (Bnip3a,Nix) is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis [2,3]. Bnip3L interacts with and suppresses the anti-apoptotic activity of Bcl-2 and Bcl-xL. Bnip3L localizes to the mitochondria and is ubiquitously expressed in human tissues [1,2,4,5].