Polyclonal Antibody to ASC (human)

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1 [1-3]. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells [3,4]. Overexpression of ASC/TMS1 induced DNA fragmentation [4]. ASC/TMS1 is expressed in a variety of human and mouse tissues [1,2].