Polyclonal Antibody to ARC (NT)

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. The CARD containing cell death regulators include RAIDD, RICK Bcl10, Apaf-1, caspase-9 and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD [1]. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue [1].