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Poly(ADP-ribose), standard

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Alternative Name	PAR
Application Notes	Immunoblotting standard for the detection of poly(ADP-ribose) (PAR) of 3-200 bases in size sythesized in vitro or in vivo.
Formulation	Liquid. In water.
MW	1’100 to 275’000 depending on the number of units of ADP-ribose.
Purity	≥95% (HPLC of ADP-ribose RNA and DNA measurement)
Quantity	1µg representing 1.8 nanomoles of 2-300 units of ADP-ribose.
Source	Released from automodified PARP-1 by base treatment and purified by boronate affinity.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for one week when stored at +4°C. Stable for at least 2 years after receipt when stored at -80°C.
Handling	Avoid freeze/thaw cycles.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Strategies Employed for the Development of PARP Inhibitors: S. Canan, et al.; Methods Mol. Biol. 1608, 271 (2017), Abstract
PARP activation promotes nuclear AID accumulation in lymphoma cells: S. Tepper, et al.; Oncotarget 7, 13197 (2016), Abstract — Full Text
Serine is a new target residue for endogenous ADP-ribosylation on histones: Leidecker, O., Bonfiglio, J. J., et al.; Nat. Chem. Biol. 12, 998 (2016), Abstract
Poly(ADP-ribose) turnover in quail myoblast cells: relation between the polymer level and its catabolism by glycohydrolase: E.B. Affar, et al.; Mol. Cell. Biochem. 193, 127 (1999), Abstract
Immunological determination and size characterization of poly(ADP- ribose) synthesized in vitro and in vivo: E.B. Affar, et al.; Biochim. Biophys. Acta 1428, 137 (1999), Abstract
Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo: E.B. Affar, et al.; Anal. Biochem. 259, 280 (1998), Abstract
Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo.: G.M. Shah, et al.; Anal. Biochem. 227, 1 (1995), Abstract
Rapid assay of poly(ADP-ribose) glycohydrolase: L. Menard & G.G. Poirier; Biochem. Cell Biol. 65, 668 (1987), Abstract

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