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POBN (high purity)

ALX-430-091

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Spin trapping reagent

Cell permeable hydrophilic spin trap for both in vivo and in vitro studies. Water soluble analog of PBN (Prod. No. ALX-430-082). Low paramagnetic impurities. No further purification required.

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Product Details

Alternative Name	α-(4-Pyridyl 1-oxide)-N-tert-butylnitrone
Appearance	White to off-white or colorless crystalline solid.
CAS	66893-81-0
Formula	C₁₀H₁₄N₂O₂
MW	194.2
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO, water, methanol or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Singlet oxygen production by photosystem II is caused by misses of the oxygen evolving complex: H. Mattila, et al.; New Phytol. 237, 113 (2023), Abstract
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med. 45, 866 (2008), Abstract
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis: K. Stadler, et al.; Am. J. Physiol. Endocrinol. Metab. 295, E456 (2008), Abstract
Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning: M.B. Kadiiska, et al.; Chem. Res. Toxicol. 11, 1516 (1998), Abstract
The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem. 270, 29265 (1995), Abstract — Full Text
Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells: L.S. Alexander-North, et al.; J. Lipid Res. 35, 1773 (1994), Abstract
In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study: L. Goria-Gatti, et al.; Carcinogenesis 13, 799 (1992), Abstract
Two decades of spin trapping: E.G. Janzen & D.L. Hare; Adv. Radic. Chem. 1, 253 (1990)

Related Products

PBN

ALX-430-082

Spin trapping reagent

20 citations

Alternative Name	N-tert-Butyl-α-phenylnitrone
CAS	3376-24-7
Purity	≥98% (HPLC)

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POBN (high purity)

ALX-430-091

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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