PNU-74654

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Catenin blocker

Anti-tumor agent that disrupts the canonical Wnt/β-catenin pathway via blockage of the protein-protein interaction between β-catenin and TCF.

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Alternative Name	2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
Appearance	Off-white solid.
CAS	113906-27-7
Couple Target	Catenin
Couple Type	Blocker
Formula	C₁₉H₁₆N₂O₃
MW	320.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25 mg/ml) and in 100% ethanol (8 mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 6 months after receipt when stored at -20°C.
Handling	Solutions can be stored at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL: Y.A. Albalawi, et al.; Viruses 14, 1469 (2022), Abstract
Inhibition of protein-protein interactions: The discovery of druglike ß-catenin inhibitors by combining virtual and biophysical screening: J.-Y. Trosset, et al.; Proteins 64, 60 (2006), Abstract
Mining the Wnt pathway for cancer therapeutics: N. Barker & H. Clevers; Nat. Rev. Drug Discov. 5, 997 (2006), Abstract

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