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PNU-282987

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Nicotinic acetylcholine receptor activator

A highly selective α7 nicotinic acetylcholine receptor agonist and prototypical novel therapeutic for schizophrenia.

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Appearance	White to off-white solid
CAS	123464-89-1
Couple Target	Acetylcholine receptor
Couple Type	Activator
Formula	C₁₄H₁₇ClN₂O
MW	264.8
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (20 mg/ml), water (6 mg/ml) or ethanol (6 mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to one year. Store solutions at -20°C for up to three months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation: C.J. Siok, et al.; Eur. J. Neurosci. 23, 570 (2006), Abstract
The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats: M. Hajos, et al.; J. Pharmacol. Exp. Ther. 312, 1213 (2005), Abstract — Full Text

Last modified: May 29, 2024

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