PLX4720

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Potent and selective B-Raf V600E inhibitor

Equally potent to c-Raf-1 (Y340D and Y341D mutations), and shows 10-fold selectivity for B-Raf V600E over wild-type B-Raf.

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Alternative Name	N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Appearance	Beige powder.
CAS	918505-84-7
Couple Target	Raf
Couple Type	Inhibitor
Formula	C₁₇H₁₄ClF₂N₃O₃S
Identity	Determined by EM-MS, NMR
MW	413.8
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO (83mg/ml) or ethanol (1mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

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