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PKI (6-22) amide

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PKA inhibitor

Competitive inhibitor of PKA (K_i =1.7 nM).

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Alternative Name	cAMP-dependent protein kinase inhibitor (6-22) amide
Appearance	Solid.
CAS	121932-06-7
Formulation	Lyophilized. Trifluoroacetate salt.
MW	1868
Purity	≥97% (HPLC)
Sequence	Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Solubility	Soluble in water (10 mg/ml).
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance: Y. Hashimotodani, et al.; Neuron 95, 928 (2017), Abstract — Full Text
Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein: D.B. Glass, et al.; J. Biol. Chem. 264, 8802 (1989), Abstract — Full Text

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