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PKI (14-22) amide (myristoylated)

BML-P210

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PKA inhibitor

Heat-stable protein kinase inhibitor (PKI) peptide sequence (14-22). N-terminus is myristoylated to increase cell membrane permeability. The non-myristoylated version of this peptide is a highly specific inhibitor of cAMP-dependent protein kinase (PKA) with K_i=36 nM. This product is a useful tool for studying PKA in cellular systems.

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Product Details

Alternative Name	cAMP-dependent protein kinase inhibitor (14-22) amide (myristoylated)
Appearance	Solid.
CAS	201422-03-9
Formula	C₅₃H₁₀₀N₂₀O₁₂
Formulation	Lyophilized. Trifluoroacetate salt.
MW	1209.5
Purity	≥95% (HPLC)
Sequence	N-myristoyl-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
Solubility	Soluble to at least 1mg/ml in water.
Source	Synthetic.
Technical Info / Product Notes	Replacement for ADI-HPK-108</strong

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from moisture.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability: B. Cali, et al.; Sci. Signal. 15, eabk2552 (2022), Abstract
Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus: Daley, E. J., Pajevic, P. D., et al.; JBMR Plus 3, e10212 (2019), Abstract
BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone: F. Ye, et al.; J. Cell Biol. 217, 1847 (2018), Abstract — Full Text
Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages: D.K. Lee, et al.; FEBS Lett. 589, 2859 (2015), Abstract
Crosstalk Between Purinergic Receptors and Canonical Signaling Pathways in the Mouse Salivary Gland: S. Bhattacharya, et al.; Cell Calcium 58, 589 (2015), Abstract
Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory: T. Gould, et al.; Neurobiol. Learn. Mem. 109, 151 (2014), Application(s): EIA using mouse hippocampal tissue, Abstract — Full Text
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC): Pavlov, T. S., Ilatovskaya, D. V., et al.; Am. J. Physiol. Renal Physiol. 301, F672 (2011), Abstract
Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP: K. Pahan et al.; J. Lipid. Res. 39, 1091 (1998), Abstract
Regulation of a common, low-affinity binding site for primary prostanoids on bovine aortic endothelial cells: G. Rimon et al.; Biochim. Biophys. Acta. 1380, 289 (1998), Abstract
Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion: T. E. Harris et al.; Biochem. Biophys. Res. Commun. 232, 648 (1997), Abstract

Last modified: May 29, 2024

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PKI (14-22) amide (myristoylated)

BML-P210

Product Details

Handling & Storage

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