Home Shop PKCζ pseudosubstrate (myristoylated)

PKCζ pseudosubstrate (myristoylated)

ALX-260-155

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Selective cell permeable inhibitor of PKCζ. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.

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Product Details

Alternative Name	Protein kinase Cζ pseudosubstrate, PKCζ (113-125) (myristoylated)
Appearance	White to off-white powder.
Formula	C₉₀H₁₅₄N₃₀O₁₇
Formulation	Counter Ion: TFA
MW	1928.4
Peptide Content	≥60%
Purity	≥95% (HPLC)
Sequence	N-Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Solubility	Soluble in water, DMSO or water-methanol (50:50) .

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways: M. Bouvet, et al.; Cell Death Discov. 7, 41410 (2021), Abstract
The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor: A. Khodorova, et al.; Neuroscience 340, 384 (2017), Reactant(s): Rat, Abstract — Full Text
The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages: A.W. Lee; PLoS One 6, e25580 (2011), Abstract — Full Text
Peptides modified by myristoylation activate eNOS in endothelial cells through Akt phosphorylation: K. Krotova, et al.; Br. J. Pharmacol. 148, 732 (2006), Abstract

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PKCζ pseudosubstrate (myristoylated)

ALX-260-155

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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