PK-11195

BML-CM118

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Benzodiazepine receptor ligand

PK-11195 is a ligand of the mitochondrial benzodiazepine receptor and selective antagonist of benzodiazepine. It facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection.

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Product Details

Appearance	White crystalline powder.
CAS	85532-75-8
Couple Target	Benzodiazepine receptor
Couple Type	Ligand
Formula	C₂₁H₂₁CIN₂O
Identity	Determined by 1H-NMR.
MW	352.9
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol, methanol, dichlormethane or DMSO. Insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection: T. Hirsch, et al.; Exp. Cell. Res. 241, 426 (1998), Abstract
Differential binding properties of the peripheral-type benzodiazepine ligands [3H]PK 11195 and [3H]Ro 5-4864 in trout and mouse brain membranes: A.J. Eshleman & T.F. Murray; J. Neurochem. 53, 494 (1989), Abstract
Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers: A. Ferry, et al.; Fundam. Clin. Pharmacol. 3, 383 (1989), Abstract
Photoaffinity labeling of peripheral-type benzodiazepine-binding sites: A. Doble, et al.; Mol. Pharmacol. 31, 42 (1987), Abstract
Dihydropyridine and peripheral type benzodiazepine binding sites: subcellular distribution and molecular size determination: A. Doble, et al.; Eur. J. Pharmacol. 119, 153 (1985), Abstract
Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies: G. Le Fur, et al.; Life Sci. 33, 449 (1983), Abstract

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PK-11195

BML-CM118

Product Details

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