PJ-34

ALX-270-289

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PARP inhibitor

Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC₅₀=20nM compared to EC₅₀=200µM of the prototypical PARP inhibitor 3-aminobenzamide (Prod. No. ALX-270-044)). Inhibits peroxynitrite (Prod. No. ALX-400-036)-induced cell necrosis (EC₅₀=20nM). Has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.

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Product Details

Alternative Name	N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide . HCl
Appearance	White to light brown or yellow powder.
CAS	344458-15-7
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₁₇H₁₇N₃O₂ . HCl
Identity	Determined by 1H-NMR.
MW	295.2 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (up to 30mg/ml) or water (up to 20mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for 2 years after receipt when stored at +4C° (desiccated). Stock solutions are stable for 3 weeks when stored at room temperature.
Handling	Hygroscopic.
Short Term Storage	Ambient
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency: Gatti, M., Imhof, R., et al.; Cell Rep. 32, 107985 (2020), Abstract
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2: Wang, C., Xu, W., et al.; Nat. Commun. 10, 1203 (2019), Abstract
MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair: Ruiz, P. D., Hamilton, G. A., et al.; Mol. Cell. Biol. 40, (2019), Abstract
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance: J. Michelena, et al.; Nat. Commun. 9, 2678 (2018), Abstract — Full Text
Necrosis triggered byi>Mycobacterium tuberculosis/i>alters macrophage triglyceride metabolism and inflammatory response in a DGAT1 – dependent manner: Jaisinghani, N., Dawa, S., et al.; bioRxiv , (2017)
Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells: Yu, S., Wang, X., et al.; J. Pineal Res. 63, (2017), Abstract
Microparticle-Induced Activation of the Vascular Endothelium Requires Caveolin-1/Caveolae: A.M. Andrews, et al.; PLoS One. 11, e0149272 (2016), Application(s): Endothelial cell culture, Abstract — Full Text
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract — Full Text
Regulation of bone morphogenetic protein signaling by ADP-ribosylation: Y. Watanabe, et al.; J. Biol. Chem. 291, 12706 (2016), Application(s): Cell culture, Abstract — Full Text
Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells: D. Montariello, et al.; Biochem. Pharmacol. 94, 212 (2015), Application(s): Cell Culture, Abstract

Related Products

3-Aminobenzamide

ALX-270-044

PARP inhibitor

12 citations

Alternative Name	3-AB
CAS	3544-24-9
Couple Type	Inhibitor
Purity	≥97% (GC)

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PJ-34

ALX-270-289

Product Details

Handling & Storage

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