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Piericidin A

ALX-380-235

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NADH-ubiquinone oxidoreductase inhibitor

Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.

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Product Details

Alternative Name	Piericidin A1, Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D
Appearance	Pale yellow oil.
CAS	2738-64-9
Couple Target	NADH-ubiquinone oxidoreductase
Couple Type	Inhibitor
Formula	C₂₅H₃₇NO₄
MW	415.6
Purity	≥95% (HPLC)
RTECS	YD4588000
Solubility	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO. Poorly soluble in water.
Source	Isolated from Streptomyces sp. MST-AS5364.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A genetically encoded system for oxygen generation in living cells: A.L. Markhard, et al.; PNAS 119, e2207955119 (2022), Abstract
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS: Shi, X., Reinstadler, B., et al.; Nat. Commun. 13, 2483 (2022), Abstract
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering: To, T. L., Cuadros, A. M., et al.; Cell 179, 1222 (2019), Abstract
Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response: Basit, F., Mathan, T., et al.; Front. Immunol. 9, 2489 (2018), Abstract
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death: Blecha, J., Novais, S. M., et al.; Free Radic. Biol. Med. 112, 253 (2017), Abstract
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism: Chen, W. W., Freinkman, E., et al.; Cell 166, 1324 (2016), Abstract
Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2: S. Grefte, et al.; Biochim. Biophys. Acta. 1853, 1606 (2015), Application(s): Cell Culture, Abstract
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol. 215, 243 (2008), Abstract
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta 1504, 173 (2001), Abstract
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett. 431, 34 (1998), Abstract

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Piericidin A

ALX-380-235

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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