Home Shop PIDD monoclonal antibody (Anto-1)

PIDD monoclonal antibody (Anto-1)

ALX-804-837

12 citations

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This antibody is covered by our Worry-Free Guarantee.

PIDD monoclonal antibody (Anto-1) Immunohistochemistry — **Figure 2:** Immunohistochemical staining of endogenous human PIDD in different human tissues (paraffin sections) using MAb to PIDD (Anto-1) (Prod. No. ALX-804-837). **Method:** Different human normal (A: Bronchus; B: Kidney; C: Lung) or cancer (D: Breast; E: Ovarian; F: Colo-rectal) tissues were stained with MAb to PIDD (Anto-1) by standard immunohistochemistry. *Pictures courtesy of Human Protein Atlas (www.proteinatlas.org*).“””””

substrate EDA-A1(Prod. No. ALX-522-038); Pink

Product Details

Application	IHC (PS), WB
Application Notes	Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.
Clone	Anto-1
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Mouse
Immunogen	Recombinant human PIDD death domain (aa 776-910).
Isotype	IgG1
Recommendation Dilutions/Conditions	Western Blot (1:500)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Source	Purified from ascites.
Species Reactivity	Human, Mouse
UniProt ID	Q9HB75
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Dysregulation of mTOR signalling is a converging mechanism in lissencephaly: Zhang, C., Liang, D., et al.; Nature 638, 172 (2025), Abstract
Ally or traitor: the dual role of p62 in caspase-2 regulation: Volik, P. I., Zamaraev, A. V., et al.; Cell Death Dis. 15, 827 (2024), Abstract
Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance: Garcia-Carpio, I., Braun, V. Z., et al.; EMBO J. 42, e113510 (2023), Abstract
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification.: Evans, L. T., Anglen, T., et al.; EMBO J. 40, e105106 (2021), Application(s): ICC-IF / Reactant(s): Human, Abstract
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration.: Fava, L. L., Villunger, A., et al.; Dev. Cell 52, 335 (2020), Application(s): WB / Reactant(s): Human, Mouse, Abstract
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.: Sladky, V. C., Knapp, K., et al.; EMBO Rep. 21, e50893 (2020), Application(s): WB / Reactant(s): Mouse, Abstract
PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis: Villunger, A., Westendorp, B., et al.; bioRxiv , (2020), Application(s): WB
PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway: Y.F. Lin, et al.; Nucleic Acids Res. 46, 1847 (2018), Application(s): Immunofluorescence, Abstract
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells: M. Jelinek, et al.; Cancer Cell Int. 13, 42 (2013), Application(s): Western blot, Abstract — Full Text
Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment: M. Orzaez, et al.; Cell Death Dis. 3, e415 (2012), Application(s): Western blot / Reactant(s): Human, Abstract — Full Text

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PIDD monoclonal antibody (Anto-1)

ALX-804-837

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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