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Piceatannol

ALX-270-202

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Syk inhibitor. SIRT1 activator.

Originally isolated from Euphorbia lagascae. Selective protein tyrosine kinase Syk inhibitor (IC₅₀~10 µM). In RBL-2H3 cells the selective inhibition of Syk by piceatannol results in inhibition of FcεR1-mediated signaling. Activator of human deacetylase SIRT1.

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Product Details

Alternative Name	3,4,3′,5′-Tetrahydroxy-trans-stilbene
Appearance	Off-white to light pink crystalline solid.
CAS	10083-24-6
Couple Target	SIRT, SIRT1, Syk
Couple Type	Activator, Inhibitor
Formula	C₁₄H₁₂O₄
MW	244.2
Purity	≥98% (HPLC (UV))
Solubility	Soluble in DMSO (>50mg/ml), methanol (>50mg/ml), dioxan (>50mg/ml), acetonitrile (>50mg/ml); slightly soluble in water (1mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Unstable in sodium hydroxide.
Handling	Protect from light and oxygen.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A comparison of resveratrol and other polyphenolic compounds on Notch activation and endothelial cell activity: B. LaFoya, et al.; PLoS One 14, e0210607 (2019), Abstract — Full Text
Gαs proteins Activate p72 Syk and p60-c-Src Tyrosine Kinases to Mediate Sickle Red Blood Cell Adhesion to Endothelium via LW-αvβ3 and CD44-CD44 Interactions: E. Chiou, et al.; Int. J. Biochem. Cell. Biol. 65, 40 (2015), Application(s): Cell Culture, Abstract
Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine: Subramanian, H., Grailer, J. J., et al.; J. Immunol. 188, 3223 (2012), Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003), Abstract
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells: D. Jeoung, et al.; Biotechnology Lett. 24, 463 (2002), Abstract — Full Text
Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro: C.J. Seow, et al.; Eur. J. Pharmacol. 443, 189 (2002), Abstract
Microarray analysis of piceatannol-induced changes in gene expression in human gastric cancer cells: D. Jeoung, et al.; Biotechnology Lett. 24, 463 (2002), Abstract — Full Text
Src-regulated extracellular signal-related kinase and Syk-regulated c-Jun N-terminal kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells: B. Cambien, et al.; J. Immunol. 163, 5079 (1999), Abstract — Full Text
FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells: C .Tkaczyk, et al.; Immunology 97, 333 (1999), Abstract
Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex: J. Zheng & V.D. Ramirez; BBRC 261, 499 (1999), Abstract

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Piceatannol

ALX-270-202

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