PI-103

ALX-270-460

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Inhibitor of DNA-PK, PI3 kinase and mTOR

Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo.

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Product Details

Alternative Name	3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Appearance	Off-white solid.
CAS	371935-74-9
Couple Target	DNA-PK, mTOR, PI3 kinase
Couple Type	Inhibitor
Formula	C₁₉H₁₆N₄O₃
Identity	Identity determined by MS and NMR.
MW	348.4
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (5mg/ml; warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

TRIM24 is an insulin-responsive regulator of P-bodies: W. Wei, et al.; Nat. Commun. 13, 3972 (2022), Abstract
RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α: Wang, X., Gessier, F., et al.; J. Immunol. 205, 1653 (2020), Abstract
Alternative dosing of dual PI3K and MEK inhibition in cancer therapy: Jokinen, E., Laurila, N., et al.; BMC Cancer 12, 612 (2012), Abstract
A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood 117, 5953 (2011), Abstract — Full Text
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia: F. Chiarini, et al.; Cancer Res. 69, 3520 (2009), Abstract
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell 9, 341 (2006), Abstract
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling: Z.A. Knight, et al.; Cell 125, 733 (2006), Abstract

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PI-103

ALX-270-460

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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