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Phosphatidic acid, dipalmitoyl

BML-LP103

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PKC activator

A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade.

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Product Details

Alternative Name	1,2-Dipalmitoyl-sn-glycero-3-phosphate . sodium salt, DPPA
Appearance	White solid.
CAS	169051-60-9
Couple Target	PKC
Couple Type	Activator
Formula	C₃₅H₆₈O₈P·Na
MW	670.9
Purity	≥98% (TLC)
Solubility	Fine suspension in ethanol (5mg/ml) with 15 minutes of sonication at room temperature.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention: R. Kumar Sah, et al.; Cell Death Dis. 5, 107 (2019), Abstract — Full Text
The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M.A. Rizzo, et al.; J. Biol. Chem. 275, 23911 (2000), Abstract
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M.A. Rizzo, et al.; J. Biol. Chem. 274, 1131 (1999), Abstract
A role for phospholipase D in control of mitogenesis: M.R. Boarder; Trends Pharmacol. Sci. 15, 57 (1994), Abstract

Last modified: May 29, 2024

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Phosphatidic acid, dipalmitoyl

BML-LP103

Product Details

Handling & Storage

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