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Phosphatidic acid, dioleoyl

BML-LP104

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PKC activator

A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade. Activates PKCζ.

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Product Details

Alternative Name	1,2-Dioleoyl-sn-glycero-3-phosphate . Na
Appearance	White powder.
CAS	108392-02-5
Couple Target	PKC
Couple Type	Activator
Formula	C₃₉H₇₃O₈P . Na
Identity	Determined by IR.
MW	724
Purity	≥98% (GC)
Solubility	Soluble in chloroform.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M. A. Rizzo, et al.; J. Biol. Chem. 275, 23911 (2000), Abstract — Full Text
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M. A. Rizzo, et al.; J. Biol. Chem. 274, 1131 (1999), Abstract
A role for phospholipase D in control of mitogenesis: M. R. Boarder, et al.; Trends Pharmacol Sci. 15, 57 (1994), Abstract
Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids: C. Limatola; Biochem. J. 304, 1001 (1994), Abstract

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Phosphatidic acid, dioleoyl

BML-LP104

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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