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Phorbol 12,13-dibutyrate

BML-PE135

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PKC activator

Widely used PKC activator (10-100ng/ml). Less potent than phorbol 12-.myristate 13-acettate (PMA; TPA) (Prod. No. BML-PE160), but also less hydrophobic.

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Product Details

Appearance	Colorless oil.
CAS	37558-16-0
Couple Target	PKC
Couple Type	Activator
Formula	C₂₈H₄₀O₈
MW	504.6
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Multiple transduction pathways mediate thyrotropin receptor signaling in preosteoblast-like cells: A. Boutin, et al.; Endocrinology 157, 2173 (2016), Application(s): Cell culture, Abstract — Full Text
Elevated Protein Kinase D3 (PKD3) Expression Supports Proliferation of Triple-negative Breast Cancer Cells and Contributes to mTORC1-S6K1 Pathway Activation: B. Huck, et al.; J. Biol. Chem. 289, 3138 (2014), Application(s): Treatment of MDA-MB-231 cell culture, Abstract — Full Text
Phorbol esters: structure, biological activity, and toxicity in animals: G. Goel, et al.; Int. J. Toxicol. 26, 279 (2007), Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva et al.; Eur. J. Pharmacol. 491, 101 (2004), Abstract
Effect of phorbol 12, 13-dibutyrate on ligand binding, enzyme activity and translocation of protein kinase C isoforms in the alpha T3-1 gonadotrope-derived cell line: M.S. Johnson et al.; Mol. Cell. Biochem. 165, 65 (1996), Abstract
Okadaic acid stimulates ouabain-sensitive 86Rb(+)-uptake and phosphorylation of the Na+/K(+)-ATPase alpha-subunit in rat hepatocytes: C.J. Lynch et al.; FEBS Lett. 355, 157 (1994), Abstract
Raf-1 and ERK2 kinases are required for phorbol 12,13-dibutyrate-stimulated proliferation of rat lymphoblasts. ERK2 activation precedes Raf-1 hyperphosphorylation: C. Lisbona et al.; Eur. J. Immunol. 24, 2746 (1994), Abstract
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells: J.P. Middleton et al.; J. Biol. Chem. 268, 15958 (1993), Abstract
Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells: T.L. Yue et al.; Neurochem. Res. 17, 997 (1992), Abstract
Phorbol-12,13-dibutyrate-induced vasoconstriction in vivo: characterization of response in genetic hypertension: G.E. Bilder et al.; J. Pharmacol. Exp. Ther. 252, 526 (1990), Abstract