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Phorbol 12-myristate 13-acetate

BML-PE160

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PKC activator

PKC activator (10-100 ng/ml). Most commonly used phorbol ester. Causes an extremely wide range of effects in cells and tissues. Very potent mouse skin tumor promoter. Inhibits apoptosis induced by Fas, but induces apoptosis in HL-60 promyelocytic leukemia cells.

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Product Details

Alternative Name	PMA, TPA
Appearance	Colorless amorphous film or foam.
CAS	16561-29-8
Couple Target	PKC
Couple Type	Activator
Formula	C₃₆H₅₆O₈
MW	616.8
Purity	≥99% (HPLC, TLC)
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Dissolve in an organic solvent prior to dilution into aqueous buffers. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous buffer. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome-lysosome Fusion in NSCLC: Guo, W., Zhou, H., et al.; Adv. Sci. (Weinh.) 11, e2308307 (2024), Abstract
S100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function: Tu, X., Chen, L., et al.; J. Exp. Clin. Cancer Res. 43, 72 (2024), Abstract
Reconstruction of Glutathione Metabolism in the Neuronal Model of Rotenone-Induced Neurodegeneration Using Mass Isotopologue Analysis with Hydrophilic Interaction Liquid Chromatography-Zeno High-Resolution Multiple Reaction Monitoring: L. Huang, et al.; Anal. Chem. 95, 3255 (2023), Abstract
Anti-Inflammatory Effects of Minor Cannabinoids CBC, THCV, and CBN in Human Macrophages: Gojani, E. G., Wang, B., et al.; Molecules 28, (2023), Abstract
STING agonism turns human T cells into interferon-producing cells but impedes their functionality: Kuhl, N., Linder, A., et al.; EMBO Rep. 24, e55536 (2023), Abstract
Anti-Inflammatory Properties of Eugenol in Lipopolysaccharide-Induced Macrophages and Its Role in Preventing β-Cell Dedifferentiation and Loss Induced by High Glucose-High Lipid Conditions: Gojani, E. G., Wang, B., et al.; Molecules 28, (2023), Abstract
Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development: Wang, X., He, Q., et al.; Immunity 56, 58 (2023), Abstract
Nanoscale organization of the endogenous ASC speck: Glück, I. M., Mathias, G. P., et al.; iScience 26, 108382 (2023), Abstract
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network: Schmacke, N. A., O’Duill, F., et al.; Immunity 55, 2271 (2022), Abstract
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses: M.E. Cook, et al.; Sci. Immunol. 7, eabo0981 (2022), Abstract

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Last modified: May 29, 2024

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Phorbol 12-myristate 13-acetate

BML-PE160

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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