Phloretin

BML-EI154

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PKC inhibitor

Flavonoid. Protein kinase C (PKC) inhibitor. PGF_2a receptor antagonist. In astrocytes, these receptors are linked to phospholipase C, thus affecting phosphoinositide hydrolysis and intracellular Ca²⁺ levels. Inhibits myo-inositol uptake and 5’-iodothyronine deiodinase. Prevents TNF-α stimulated upregulation of VCAM-1, ICAM-1 and E-selectin. Enhances adiponectin expression.

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Product Details

Appearance	Off-white to beige solid.
CAS	60-82-2
Couple Target	PKC, Prostaglandin receptor
Couple Type	Inhibitor
Formula	C₁₅H₁₄O₅
Identity	Determined by 1H-NMR and MS.
MI	14: 7326
MW	274.3
Purity	≥98% (TLC)
Solubility	Soluble in acetone, DMSO, 100% ethanol or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Product may air oxidize in solution. Make solutions fresh daily.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells: M. Hassan, et al.; BBRC 361, 208 (2007), Abstract
The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets: V. Stangl, et al.; J. Nutr. 135, 172 (2005), Abstract
Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae: T. Kasahara & M. Kasahara; Biochem. J. 315 (Pt1), 177 (1996), Abstract
Functional differentiation of the human red blood cell and kidney urea transporters: S. Martial, et al.; Am. J. Physiol. 271, F1264 (1996), Abstract
Cloning and functional expression of a urea transporter from human bone marrow cells: B. Olives, et al.; J. Biol. Chem. 269, 31649 (1994), Abstract
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C: N. Prevarskaya, et al.; Mol. Cell. Neurosci. 5, 699 (1994), Abstract
Thyroid hormones in tissues from fetal and adult rats: G. Morreale de Escobar; Endocrinology 134, 2410 (1994), Abstract
Activating effect of the flavonoid phloretin on Ca(2+)-activated K+ channels in myelinated nerve fibers of Xenopus laevis: D.S. Koh, et al.; Neurosci. Lett. 165, 167 (1994), Abstract
The effect of glucose and galactose toxicity on myo-inositol transport and metabolism in human skin fibroblasts in culture: G.T. Berry, et al.; Pediat. Res. 35, 141 (1994), Abstract
Cloning and characterization of the vasopressin-regulated urea transporter: G. You, et al.; Nature 365, 844 (1993), Abstract

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Phloretin

BML-EI154

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