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PHC-SKKKK . 3 TFA

ALX-165-071

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Negative control for Pam₃Cys-Ser-(Lys)₄ . trihydrochloride

Does not activate TLR2. Can be used as negative control for Pam3Cys-Ser-(Lys)4 . trihydrochloride (Prod. No. ALX-165-066).

Lipopeptides are valuable tools for basic research in innate and acquired immunity. PHC-SKKKK (PHC-SK4) and Pam₃Cys-SKKKK (P3SK4) (Prod. No. ALX-165-066) have similar physicochemical properties, both have three fatty acid residues and the same peptide moiety. In contrast to P3SK4, PHCSK4 is not an activator of TLR2.

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Product Details

Alternative Name	PHCSK4 . 3 TFA, N-palmitoyl-S-(1,2-bishexadecyloxy-carbonyl)-ethyl-(R)-cysteinyl-seryl-(lysyl)3-lysine . 3 CF3COOH
Appearance	Colorless powder
Concentration	1mg/ml after reconstitution.
Formula	C₈₂H₁₅₈N₁₀O₁₃S . 3 CF₃COOH
Formulation	Lyophilized.
MW	1524.3 . 342.1
Quality Control	Confirmed by ESI-MS.
Reconstitution	Reconstitute with 1 mL pyrogen-free deionized water in a pyrogen-free tube. Reconstitution can also be performed in DMSO (1mg/ml stock solution). Homogenize by vortexing or use a homogenizer or sonicator to prepare a homogenous solution. Further dilutions can be made with cell culture medium or pyrogen-free deionized water. PBS is not recommended for reconstitution or dilution.
Solubility	Soluble in pyrogen-free deionized water, DMSO or aqueous buffers at pH <7.5
Source	Synthetic

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation: D.T. Nguyen, et al.; PLoS Pathog. 6, e1001049 (2010), Abstract
Synthetic bacterial lipopeptide analogs: structural requirements for adjuvanticity: M. Ghielmetti, et al.; Immunobiology 210, 211 (2005), Abstract
Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes: G. Meng, et al.; J. Clin. Invest. 113, 1473 (2004), Abstract
The ester-bonded palmitoyl side chains of Pam3CysSerLys4 lipopeptide account for its powerful adjuvanticity to HLA class I-restricted CD8+ T lymphocytes: A. Reschner, et al.; Eur. J. Immunol. 33, 2044 (2003), Abstract

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PHC-SKKKK . 3 TFA

ALX-165-071

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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PHC-SKKKK . 3 TFA

ALX-165-071

Product Details

Handling & Storage

Related Products

Pam3Cys-Ser-(Lys)4 . trihydrochloride

ALX-165-066

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Pam₃Cys-Ser-(Lys)₄ . trihydrochloride