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Phallacidin

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Actin ligand

Biological activity like phalloidin (Prod. No. ALX-350-265), but contains a carboxy group for coupling reactions.

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Alternative Name	EL-Phallacidin
Appearance	White to off-white powder.
CAS	26645-35-2
Couple Target	Actin
Couple Type	Ligand
Formula	C₃₇H₅₀N₈O₁₃S
MW	846.9
Purity	≥90%
Solubility	Soluble in DMF, DMSO, 100% methanol, and water.
Source	Isolated from Amanita phalloides mushrooms.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

First report of a neotropical Agaric (Lepiota spiculata, Agaricales, Basidiomycota) containing lethal α-amanitin at toxicologically relevant levels: C. Angelini, et al.; Front. Microbiol. 11, 1833 (2020), Abstract — Full Text
Highly sensitive determination of amanita toxins in biological samples using β-cyclodextrin collaborated molecularly imprinted polymers coupled with ultra-high performance liquid chromatography tandem mass spectrometry: L. Tan, et al.; J. Chromatogr. A 1630, 461514 (2020), Abstract
Toxin components and toxicological importance of Galerina marginata from Turkey: I. Akata, et al.; Toxicon 187, 29 (2020), Abstract
Two new species of Amanita sect. Phalloideae from Africa, one of which is devoid of amatoxins and phallotoxins: A. Fraiture, et al.; MycoKeys 53, 93 (2019), Abstract — Full Text
Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin: P.G. Phillips, et al.; Am. J. Physiol. 257, C562 (1989), Abstract
Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin: L.S. Barak, et al.; PNAS 77, 980 (1980), Abstract

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