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GABA_B receptor antagonist

Selective GABA_B receptor antagonist. Antagonizes the postsynaptic action of baclofen (Prod. No. BML-EA128).

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Alternative Name	(±)-3-Amino-2-(4-chlorophenyl)-propylphosphomic acid
Appearance	White solid.
CAS	114012-12-3
Couple Target	GABA receptor
Couple Type	Ligand
Formula	C₉H₁₃ClNO₃P
Identity	Determined by 1H-NMR and MS.
MW	249.6
Purity	≥98% (HPLC)
Solubility	Soluble in water, methanol or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes: Y. Kamisaki, et al.; Brain Res. 627, 181 (1993), Abstract
gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor: G. Bonanno & M. Raiteri; J. Pharmacol. Exp. Ther. 265, 765 (1993), Abstract
A physiological role for GABAB receptors in the central nervous system: P. Dutar & R.A. Niccol; Nature 332, 156 (1988), Abstract
Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons: H. Hasuo & J.P. Gallagher; Neurosci. Lett. 86, 77 (1988), Abstract
Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex: G. Karlsson, et al.; Eur. J. Pharmacol. 148, 485 (1988), Abstract
Phaclofen: a peripheral and central baclofen antagonist: D.I. Kerr, et al.; Brain Res. 405, 150 (1987), Abstract

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