PGF_2α receptor (FP) polyclonal antibody

Arachidonic acid is converted by cyclooxygenase (COX) to prostaglandin H2 (PGH2), which is further converted to the derivative prostanoids PGD2, PGE2, PGF2α, PGI2 (prostacyclin) and thromboxane A2 (TXA2). Five classes of prostanoid receptors are recognized and named DP, EP, FP, IP and TP receptors corresponding to the agonist properties of the associated prostanoids. FP receptors are found in smooth muscle where they mediate contraction, and are believed to be coupled via Gq/11 subunits to stimulate phosphatidyl inositol (PI) hydrolysis. The FP agonist Fluprostenol (a PGF2α analogue) is used in animal husbandry to synchronize oestrus and induce partruition. FP receptors are known to mediate intraocular pressure, and FP agonists such as latanoprost and travoprost are drugs commonly use to treat glaucoma.