PGE2 high sensitivity ELISA kit

• Ultrasensitive measurement, detecting as little as 8.26 pg/ml PGE₂
• Validated in a wide variety of sample matrices
• Reliable and reproducible results lot-after-lot and day-after-day
• Fully quantitative results that surpass semi-quantitative Western blot analysis

The PGE₂ high sensitivity ELISA kit is a colorimetric competitive enzyme immunoassay kit with results overnight + 1 hour.

Prostaglandin E₂ (PGE₂) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH₂), which is further metabolized by PGE synthases into its major product, PGE₂. PGE₂ mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE₂ has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE₂ production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.