Highly sensitive PGE2 ELISA kit for inflammation and eicosanoid research.
- Highly sensitive measurement, detecting as little as 13.4 pg/ml PGE2
- Higher throughput format with results in <3 hrs for up to 37 samples in duplicate
- Widely cited in peer reviewed literature
- Ready-to-use liquid color-coded reagents reduce errors
- Reproducible results day-after-day and lot-to-lot
The PGE2 EIA kit is a colorimetric competitive enzyme immunoassay kit with results in < 3 hours. Absorbance is read at 405 nm. Screen inhibitors of COX II activity by measuring the levels of downstream PGE2. Commercially available since 1992, this kit is widely cited in peer-reviewed publications. The non-radioactive ready-to-use liquid color-coded reagents reduce errors.
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.
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Product Details
Alternative Name |
Prostaglandin E2 |
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Application |
Colorimetric detection, ELISA |
Application Notes |
For the quantitative determination of PGE2 in culture supernatants, serum, saliva, urine, and whole blood from any species. Cited sample types include cerebral spinal fluid, dialysate, gingival crevicular fluid, peritoneal exudate fluid and peritoneal exudate cell supernatant, plasma, and tissue. |
Compatibility |
This product is compatible with the Absorbance 96 Plate Reader. |
Contents |
GxM IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution |
Sensitivity |
13.4 pg/ml (range 39.1 – 2,500 pg/ml) |
Species Reactivity |
Species independent |
Wavelength |
405 nm |
Handling & Storage
Use/Stability |
Store all components at +4°C, except standard and conjugate at -20°C. |
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Shipping |
Blue Ice |
Regulatory Status |
RUO – Research Use Only |
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- Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming: Pham, D. V., Nguyen, T. K., et al.; Acta Pharm. Sin. B 14, 273 (2024), Abstract
- Binding Affinity Screening of Polyphenolic Compounds in Stachys Affinis extract (SAE) for their Potential Antioxidant and Anti- inflammatory Effects: Kim, H. H., Jeong, S. H., et al.; Research Square , (2024)
- Binding affinity screening of polyphenolic compounds in Stachys affinis extract (SAE) for their potential antioxidant and anti-inflammatory effects: Kim, H. H., Jeong, S. H., et al.; Sci. Rep. 14, 18095 (2024), Abstract
- Decreased Expression of IL-35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia: Cai, X., Gui, R. Y., et al.; Adv. Sci. (Weinh.) 11, e2305798 (2024), Abstract
- Impact of a varied set of stimuli on a suite of immunological parameters within peripheral blood mononuclear cells: toward a non-animal approach for assessing immune modulation by materials intended for human use: Cochrane, S., Rajagopal, R., et al.; Front. Toxicol. 6, 1335110 (2024), Abstract
- Interleukin-1 Beta (IL1B) and Nerve Growth Factor (NGF): Key Players in Rabbit Reproductive Regulation: Guelfi, G., Dall’Aglio, C., et al.; Int. J. Mol. Sci. 25, (2024), Abstract
- Microglia determine an immune-challenged environment and facilitate ibuprofen action in human retinal organoids: Schmied, V., Korkut-Demirbaş, M., et al.; bioRxiv , (2024)
- PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis: M. Israr, et al.; Eur. J. Immunol. , e2250036 (2023), Abstract
- Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models: S.H. Tseng, et al.; J. Tradit. Complement. Med. 13, 51 (2023), Abstract
- Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System: S. Schiffmann, et al.; Int. J. Mol. Sci. 24, 5872 (2023), Abstract
- Effects of 2-carba-cyclic phosphatidic acid derivatives on IL-1β-stimulated human chondrocytes: M. Yoshii, et al.; Prostaglandins Other Lipid Mediat. 164, 106699 (2023), Abstract
- Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer’s disease: S.M. Wang, et al.; Heliyon 9, e15406 (2023), Abstract
- Genomic analysis in the colon tissues of omega-3 fatty acid-treated rats identifies novel gene signatures implicated in ulcerative colitis: J. Magisetty, et al.; Int. J. Biol. Macromol. 258, 128867 (2023), Abstract
- Glycolipid-enriched fraction of Osmanthus fragrans inhibits LPS-induced expression of inflammatory genes, COX-2, E-selectin, and Interleukin-8: T. Pirker, et al.; J. Ethnopharmacol. 309, 116328 (2023), Abstract
- In vitro and in silico studies of 7′′,8′′-buddlenol D anti-inflammatory lignans from Carallia brachiata as p38 MAP kinase inhibitors: N. Nalinratana, et al.; Sci. Rep. 13, 3558 (2023), Abstract
- In vitro and in vivo anti-osteoarthritis effects of tradition Chinese prescription Ji-Ming-San: C.Y. Hsieh, et al.; J. Ethnopharmacol. 305, 116084 (2023), Abstract
- Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes: A. Gainullina, et al.; Cell Rep. 42, 112046 (2023), Abstract
- UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract: J.S.K. Stanković, et al.; Molecules 28, 1274 (2023), Abstract
- Inhibitory effects of polysaccharides from Korean ginseng berries on LPS-induced RAW264.7 macrophages: W. Rod-In, et al.; PLoS One 18, e0294675 (2023), Abstract
- Xuelian injection ameliorates complete Freund’s adjuvant-induced acute arthritis in rats via inhibiting TLR4 signaling: L.S. Yan, et al.; Heliyon 9, e21635 (2023), Abstract
- Reactive Oxygen Species-Dependent Activation of EGFR/Akt/p38 Mitogen-Activated Protein Kinase and JNK1/2/FoxO1 and AP-1 Pathways in Human Pulmonary Alveolar Epithelial Cells Leads to Up-Regulation of COX-2/PGE2 Induced by Silica Nanoparticles: Y.J. Lin, et al.; Biomedicines 11, 2628 (2023), Abstract
- Caffeic acid methyl ester inhibits LPS‑induced inflammatory response through Nrf2 activation and NF‑κB inhibition in human umbilical vein endothelial cell: J.Y. Park, et al.; Exp. Ther. Med. 26, 559 (2023), Abstract
- Potential Joint Protective and Anti-Inflammatory Effects of Integrin αvβ3 in IL-1β-Treated Chondrocytes Cells: H.H. Kim, et al.; Biomedicines 11, 2745 (2023), Abstract
- Visual quantification of prostaglandin E2 discharge from a single cell: T. Watabe, et al.; Cell Struct. Func. 48, 241 (2023), Abstract
- Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS: El-Obeid, A., Maashi, Y., et al.; BMC Complement Med. Ther. 23, 305 (2023), Abstract
- Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis: Awasthi, D., Chopra, S., et al.; J. Clin. Invest. 133, (2023), Abstract
- Mechanoregulation of Osteoclastogenesis-Inducing Potentials of Fibrosarcoma Cell Line by Substrate Stiffness: Tiskratok, W., Yamada, M., et al.; Int. J. Mol. Sci. 24, (2023), Abstract
- Sichen Formula Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Blocking the TLR4 Signaling Pathways: Yan, L. S., Cui, S., et al.; Drug Des. Devel. Ther. 17, 297 (2023), Abstract
- Substrate stiffness controls proinflammatory responses in human gingival fibroblasts: Tiskratok, W., Yamada, M., et al.; Sci. Rep. 13, 1358 (2023), Abstract
- Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells: Kuhn, A., Riegger, J., et al.; Cells 12, (2023), Abstract
- Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials: D’Amico, D., Fouassier, A., et al.; medRxiv , (2023)
- Use of Germination to Enhance Resveratrol Content and Its Anti-Inflammatory Activity in Lipopolysaccharide-Stimulated RAW264.7 Cells: Monmai, C., Kim, J. S., et al.; Molecules 28, (2023), Abstract
- Immune-modulation effect of Halocynthia aurantium tunic lipid on RAW264.7 cells: A.Y. Jang, et al.; Food Sci. Biotechnol. 31, 101 (2022), Abstract
- Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle: G. Zengin, et al.; Plants (Basel) 11, 233 (2022), Abstract
- Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages: S. Murthy, et al.; Cell Death Dis. 13, 53 (2022), Abstract
- Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways: M. Charrier, et al.; Stem Cells Res. Ther. 13, 7 (2022), Abstract
- Label-Free, Novel Electrofluidic Capacitor Biosensor for Prostaglandin E2 Detection toward Early and Rapid Urinary Tract Infection Diagnosis: A. Ganguly, et al.; ACS Sens. 7, 186 (2022), Abstract
- Infection of Galleria mellonella (lepidoptera) larvae with the entomopathogenic fungus Conidiobolus coronatus (entomophthorales) induces apoptosis of hemocytes and affects the concentration of eicosanoids in the hemolymph: A.K. Wronska, et al.; Front. Physiol. 12, 774086 (2022), Application(s): ELISA kit using hemolymph, Abstract — Full Text
- Delta-9-tetrahydrocannabinol increases vascular endothelial growth factor (VEGF) secretion through a cyclooxygenase-dependent mechanism in rat granulosa cells: A.A.M. Peña, et al.; Reprod. Toxicol. 111, 59 (2022), Abstract
- In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae): T. Mićović , et al.; J. Ethnopharmacol. 293, 115201 (2022), Abstract
- A safety evaluation of allogeneic freeze-dried platelet-rich plasma or conditioned serum compared to autologous frozen products equivalents in equine healthy joints: L.C. Garbin, et al.; BMC Vet. Res. 18, 141 (2022), Abstract
- Molecular Mechanism of Cinnamomum cassia against Gastric Damage and Identification of Active Compounds: M.J. Lee, et al.; Biomolecules 12, 525 (2022), Abstract
- Participation of lipopolysaccharide in hyperplasic adipose expansion: Involvement of NADPH oxidase/ROS/p42/p44 MAPK-dependent Cyclooxygenase-2: C.C. Chang, et al.; J. Cell. Mol. Med. 26, 3850 (2022), Abstract
- Prostaglandin E2–Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation: W. Wang, et al.; J. Immunol. 208, 1912 (2022), Abstract
- Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts: Y. Sueda, et al.; Yonoago Acta Med. 65, 111 (2022), Abstract
- Functional rewiring of G protein-coupled receptor signaling in human labor: A.R. Walker, et al.; Cell Rep. 40, 36070698 (2022), Abstract
- NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels: J. Lückgen, et al.; Stem Cell Res. Ther. 13, 168 (2022), Abstract
- Salivary inflammatory mediators as biomarkers for oral mucositis and oral mucosal dryness in cancer patients: A pilot study: A. Kiyomi, et al.; PLoS One 17, e0267092 (2022), Abstract
- Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis: D. Twilley, et al.; Pharmaceuticals 15, 1497 (2022), Abstract
- Dual inhibition of SGLT2 and DPP-4 promotes natriuresis and improves glomerular hemodynamic abnormalities in KK/Ta-Ins2Akita mice with progressive diabetic kidney disease: H. Fujita, et al.; Biochem. Biophys. Res. Commun. 635, 84 (2022), Abstract
- Gestational NSAIDs distinctly reprogram cardiac injury in preeclamptic rats: Roles of cyclooxygenase, apoptotic and autophagic trails: M.A. Ali, et al.; Life Sci. 310, 121130 (2022), Abstract
- The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway: K. Kim, et al.; BMC Complement Med. Ther. 22, 343 (2022), Abstract
- Development of fermented rice cake containing strawberry showing anti-inflammatory effect on LPS-stimulated macrophages and paw edema induced mice: Monmai, C., Choi, J., et al.; PLoS One 17, e0276020 (2022), Abstract
- Quercetin-Rich Ethanolic Extract of Polygonum odoratum var Pakphai Leaves Decreased Gene Expression and Secretion of Pro-Inflammatory Mediators in Lipopolysaccharide-Induced Murine RAW264.7 Macrophages: Chansiw, N., Champakam, S., et al.; Molecules 27, (2022), Abstract
- The Effects of Prostaglandin E2 Treatment on the Secretory Function of Mare Corpus Luteum Depends on the Site of Application: An in vivo Study: Piotrowska-Tomala, K. K., Jonczyk, A. W., et al.; Front. Vet. Sci. 8, 753796 (2022), Abstract
- Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer: Chae, C. S., Sandoval, T. A., et al.; Cancer Discov. 12, 1904 (2022), Abstract
- Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer: Kang, J., Lee, D., et al.; Cancers (Basel) 14, (2022), Abstract
- The inhibitory effect of AMP-activated protein kinase (AMPK) on chemokine and prostaglandin production in human endometrial stromal cells: Y. Kawano, et al.; Reprod. Biol. Endocrinol. 19, 188 (2021), Abstract
- Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1,3-diphenyl-1H-pyrazol-4-yl)pyridine sulfonamide derivatives: M.S. Abdel-Maksoud, et al.; Bioorg. Chem. 117, 105424 (2021), Abstract
- Synergistic effect of Korean red ginseng extract and GABA mixture on the IgE production in mice via Th1/Th2 cell balance: J.S. Lim, et al.; Food Sci. Biotechnol. 30, 1571 (2021), Abstract
- Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE2 Pathway: M.M. Tsai, et al.; J. Cancer 12, 7052 (2021), Abstract
- Assessment of Anti-Inflammatory and Antioxidant Effects of Citrus unshiu Peel (CUP) Flavonoids on LPS-Stimulated RAW 264.7 Cells: A. Karthikeyan, et al.; Plants 10, 2209 (2021), Abstract
- Effect of mesenchymal stem cells combined with chondroitin sulfate in an in vitro model of osteoarthritis: S. Pérez-Castrillo, et al.; Am. J. Transl. Res. 13, 5928 (2021), Abstract
- Antioxidants and/or fish oil reduce intermittent hypoxia-induced inflammation in the neonatal rat terminal ileum: G. Mustafa, et al.; Prostaglandins Other Lipid Mediat. 155, 106565 (2021), Abstract
- A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes: F. Appetecchia, et al.; Antioxidants 10, 1828 (2021), Abstract
- Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitors: M. Kim, et al.; Bioorg. Med. Chem. Lett. 41, 127992 (2021), Abstract
- Potential Surrogate Quantitative Immunomodulatory Potency Assay for Monitoring Human Umbilical Cord-derived Mesenchymal Stem Cells Production: S. Teng, et al.; Cell Biol. Int. 45, 1072 (2021), Abstract
- Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment: G. Ruiz-Heiland, et al.; Clin. Oral. Investig. 25, 1933 (2021), Abstract — Full Text
- Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy: Mehrabian, Z., Guo, Y., et al.; Cells 10, (2021), Abstract
- Inflammatory Markers in Uterine Lavage Fluids of Pregnant, Non-Pregnant, and Intrauterine Device Implanted Mares on Days 10 and 15 Post Ovulation: Rivera Del Alamo, M. M., Reilas, T., et al.; Animals (Basel) 11, (2021), Abstract
- Irradiated Tumor Fibroblasts Avoid Immune Recognition and Retain Immunosuppressive Functions Over Natural Killer Cells: Yang, N., Lode, K., et al.; Front. Immunol. 11, 602530 (2021), Abstract
- Genetic deletion of connexin 37 causes polyuria and polydipsia: J. Xue, et al.; PLoS One 15, e0244251 (2020), Abstract — Full Text
- Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation: M.B. Reis, et al.; Nat. Commun. 11, 5433 (2020), Abstract — Full Text
- Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats: N. Ishiuchi, et al.; Stem Cell Res. Ther. 11, 130 (2020), Abstract — Full Text
- CoCrMo surface modifications affect biocompatibility, adhesion, and inflammation in human osteoblasts: B. Lohberger, et al.; Sci. Rep. 10, 1682 (2020), Abstract — Full Text
- Artemisia iwayomogi (Dowijigi) inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing the NF-κB signaling pathway: Kim, S. M., Vetrivel, P., et al.; Exp. Ther. Med. 19, 2161 (2020), Abstract
- Culturing Articular Cartilage Explants in the Presence of Autologous Adipose Tissue Modifies Their Inflammatory Response to Lipopolysaccharide: Pearson, W., Garland, A. E. N., et al.; Mediators Inflamm. 2020, 8811001 (2020), Abstract
- Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence: De Canha, M. N., Komarnytsky, S., et al.; Front. Pharmacol. 10, 1559 (2020), Abstract
- Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids: Koundouros, N., Karali, E., et al.; Cell 181, 1596 (2020), Reactant(s): Human, Abstract
- Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases: Lim, S. Y., Dafydd, M., et al.; Int. J. Pharm. 573, 118860 (2020), Abstract
- Prostaglandin E2 affects in vitro maturation of bovine oocytes: Boruszewska, D., Kowalczyk-Zieba, I., et al.; Reprod. Biol. Endocrinol. 18, 40 (2020), Abstract
- The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium: Amaral, A., Fernandes, C., et al.; Animals (Basel) 10, (2020), Abstract
- The role of vaspin in porcine corpus luteum: Kurowska, P., Mlyczyńska, E., et al.; J. Endocrinol. 247, 283 (2020), Abstract
- Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?: M.D. Nissen, et al.; BMC Complement. Altern. Med. 19, 162 (2019), Abstract
- Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats: Y. Yonezawa, et al.; Biol. Pharm. Bull. 42, 1120 (2019), Abstract
- IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain: S. Chopra, et al.; Science 365, eaau6499 (2019), Application(s): Cell Culture Supernatant, Abstract
- Redox Control of IL-6-Mediated Dental Pulp Stem-Cell Differentiation on Alginate/Hydroxyapatite Biocomposites for Bone Ingrowth: S. Sancilio, et al.; Nanomaterials (Basel) 9, 1656 (2019), Abstract — Full Text
- The serine protease inhibitors and SERPINE1/2 disrupt prostaglandin E2 production and hyaluronic acid retention in FSH‐stimulated pig cumulus–oocyte complexes: M. Blaha, et al.; Reprod. Domest. Anim. 54, 65 (2019), Application(s): Cell culture supernatant from porcine cumulus-oocyte complexes, Abstract
- Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation: N. Taechangam, et al.; Stem Cell Res. Ther. 10, 188 (2019), Abstract — Full Text
- Molecular profiling and functional analysis of macrophage-derived tumor extracellular vesicles: C. Cianciaruso, et al.; Cell Rep. 27, 3062 (2019), Application(s): ELISA using culture supernatants, Abstract — Full Text
- Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis: F. Desmarais, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 522 (2019), Application(s): ELISA using liver homogenates, Abstract
- Anti-inflammatory effect of remifentanil in lipopolysaccharide-stimulated amniotic epithelial cells: Kim, C. H., Jeong, S. S., et al.; J. Dent. Anesth. Pain Med. 19, 253 (2019), Abstract
- Meloxicam affects the inflammatory responses of bovine mammary epithelial cells: Caldeira, M. O., Bruckmaier, R. M., et al.; J. Dairy Sci. 102, 10277 (2019), Abstract
- Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection: S. Nayak, et al.; Front. Immunol. 9, 1960 (2018), Application(s): Zebrafish kidney lysates, Abstract — Full Text
- Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase: H. Pein, et al.; Nat. Commun. 9, 3834 (2018), Application(s): Peritoneal exudates, Abstract — Full Text
- Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model: N. Kim, et al.; Biomol. Ther. (Seoul) 26, 210 (2018), Abstract — Full Text
- Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells: S.W. Saliba, et al.; J. Neuroinflammation 15, 322 (2018), Abstract — Full Text
- Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice: J.H. An, et al.; BMC Vet. Res. 14, 354 (2018), Abstract — Full Text
- Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro: D. Dan, et al.; J. Dairy Sci. 101, 11321 (2018), Abstract
- Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses: M.H. Tsai, et al.; Immunol. Lett. 203, 40 (2018), Abstract
- An ethanol extract of the rhizome of Atractylodes chinensis exerts anti-gastritis activities and inhibits Akt/NF-κB signaling: M.J. Hossen, et al.; J. Ethnopharmacol. 228, 18 (2018), Abstract
- Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells: C.W. Lee, et al.; Redox Biol. 18, 93 (2018), Abstract — Full Text
- Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study: De Colli, M., Tortorella, P., et al.; Int. J. Mol. Med. 42, 651 (2018), Abstract
- Elastase inhibition affects collagen transcription and prostaglandin secretion in mare endometrium during the estrous cycle: Amaral, A., Fernandes, C., et al.; Reprod. Domest. Anim. 53 Suppl 2, 66 (2018), Abstract
- Exploring relationships between body condition score, body fat, activity level and inflammatory biomarkers: Pearson, W., Wood, K., et al.; J Anim Physiol Anim Nutr (Berl) 102, 1062 (2018), Abstract
- Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation: Ikeya, S., Sakabe, J. I., et al.; Sci. Rep. 8, 5050 (2018), Abstract
- The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint: H.M. Heikkilä, et al.; BMC Vet. Res. 13, 74 (2017), Application(s): Canine synovial fluid and serum, Abstract — Full Text
- Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells: J.H. Cha, et al.; Nutr. Res. Pract. 11, 90 (2017), Abstract — Full Text
- Inhibitory effects of Aconiti Lateralis Radix Preparata on chronic intermittent cold-induced inflammation in the mouse hypothalamus: W. Kim, et al.; J. Ethnopharmacol. 215, 27 (2017), Abstract
- Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells: H.S. Kim, et al.; Int. J. Mol. Sci. 18, 2683 (2017), Abstract — Full Text
- Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling: X. Zhang, et al.; Neuropharmacology 128, 269 (2017), Abstract
- Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E, 4E-dienoic acid isobutylamide: T.V. Gulledge, et al.; J. Ethnopharmacol. 212, 166 (2017), Abstract
- Prostaglandin E2 stimulates the expression of cumulus expansion-related genes in pigs: the role of protein kinase B: M. Blaha, et al.; Prostaglandins Other Lipid Mediat. 130, 38 (2017), Application(s): ELISA using pig samples, Abstract
- Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome: H.C. Clark, et al.; Stem Cell Res. Ther. 8, 69 (2017), Application(s): Measurement of PGE2 in supernatant of human and feline cells., Abstract — Full Text
- Expression of toll-like receptor-1 by bradykinin in human gingival fibroblasts: J.A. Arreguin-Cano T; Int. J. Clin. Exp. Pathol. 10, 1283 (2017), Application(s): Measurement of PGE2 in supernatant., Full Text
- Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production in human breast cancer cells: H.T. Chen, et al.; Innate Immun. 23, 54 (2017), Abstract — Full Text
- Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor: Z. Drebert, et al.; Vascul. Pharmacol. 89, 19 (2017), Application(s): Determine the concentrations of prostanoids in conditioned medium from myofibroblasts and HUVECs, and in HUVEC lysates, Abstract
- Evaluation of anti-acne properties of phloretin in vitro and in vivo: H. Kum, et al.; Int. J. Cosmet. Sci. 38, 85 (2016), Application(s): HaCaT cell culture supernatant, Abstract
- Hypoxia-mediated impaired erythrocyte Lands’ Cycle is pathogenic for sickle cell disease: H. Wu, et al.; Sci. Rep. 6, 29637 (2016), Application(s): ELISA using mouse plasma, Abstract — Full Text
- Uterus-targeted liposomes for preterm labor management: studies in pregnant mice: J.S. Refuerzo, et al.; Sci. Rep. 6, 34710 (2016), Abstract — Full Text
- Enhanced biocompatible and hemocompatible nano/micro porous surface as a biological scaffold for functionalizational and biointegrated implants: S.F. Chu, et al.; J. Alloys Compd. 684, 726 (2016)
- Enhanced anti-inflammatory activity of brown seaweed Laminaria japonica by fermentation using Bacillus subtilis: H.T.V. Lin, et al.; Process Biochem. 51, 1945 (2016), Application(s): Measurement of prostaglandin E2 (PAGE2), cell supernatant
- The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation: X. Wang, et al.; PLoS One 12, e1005803 (2016), Application(s): PGE2 measurement in cell lysates, Abstract — Full Text
- Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age: X. Capo, et al.; Nutrients 8, 619 (2016), Application(s): Cytokine, Eicosanoids and Adhesion Molecules Determination, plasma, Abstract — Full Text
- Local intra-uterine Ang-(1-7) infusion attenuates PGE2 and 6-keto PGF1α in decidualized uterus of pseudopregnant rats: K.B. Brosnihan, et al.; Reprod. Biol. Endocrinol. 14, 68 (2016), Application(s): Assaying tissue extracts, Abstract — Full Text
- MRI-Based Assessment of Intralesional Delivery of Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Equine Tendonitis: A. Scharf, et al.; Stem Cells Int. 2016, 1 (2016), Application(s): Assessing the ability of MSCs to modulate the inflammatory response, Abstract — Full Text
- Anti-inflammatory effects of 6′-O-acetyl mangiferin from Iris rossii Baker via NF-κb signal blocking in lipopolysaccharide-stimulated RAW 264.7 cells: J.H. Jang, et al.; Chem. Biol. Interact. 2797, 30303 (2016), Application(s): Determination of PGE2 production, Abstract
- Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways: Q. Yu, et al.; Int. Immunopharmacol. 38, 104 (2016), Application(s): PGE2 was measured in mouse supernatant, Abstract
- A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells: K. Tamura, et al.; Prostaglandins Other Lipid Mediat. 123, 56 (2016), Application(s): Measurement of PGE2 in the culture media, Abstract
- Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cells: S.E. Fiedler, et al.; Biochem. Biophys. Res. Commun. 475, 19 (2016), Application(s): Supernatant PGE2 was measured, Abstract
- In vitro bioactive properties of phlorotannins recovered from hydrothermal treatment of Sargassum muticum: M.P. Casas, et al.; Sep. Purif. Technol. 167, 117 (2016), Application(s): Determination of the amount of PGE2 in thawed plasma supernatants
- Grid-like surface structures in thermoplastic polyurethane induce anti-inflammatory and anti-fibrotic processes in bone marrow-derived mesenchymal stem cells: Y. Roger, et al.; Colloids Surf. B Biointerfaces 148, 104 (2016), Application(s): ELISA using human bone marrow-derived mesenchymal stem cell supernatant, Abstract
- Isolation and Identification of a Flavone Apigenin from Marine Red Alga Acanthophora spicifera with Antinociceptive and Anti-Inflammatory Activities: G.A. El Shoubaky, et al.; J. Exp. Neurosci. 10, 21 (2016), Application(s): TNF-α measured in mouse blood samples, Abstract — Full Text
- Implantation and pregnancy outcome of Sprague-Dawley rats fed with low and high salt diet: G.O. Oludare, et al.; Middle East Fertil. Soc. J. 21, 228 (2016), Application(s): Measured rat serum PGE2 levels
- Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia: Y.S. Chiou, et al.; Free. Radic. Biol. Med. 94, 1 (2016), Application(s): Measurement of prostaglandin E2 (PGE2) level in culture medium, Abstract
- Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice: Li, Y., Cui, S. X., et al.; Oncotarget 7, 60446 (2016), Abstract
- Dimethyl celecoxib sensitizes gastric cancer cells to ABT-737 via AIF nuclear translocation: Zhang, B., Yan, Y., et al.; J. Cell. Mol. Med. 20, 2148 (2016), Abstract
- Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney: L. Pelligand, et al.; BMC Vet. Res. 11, 296 (2015), Abstract — Full Text
- Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake: M. Labrie, et al.; PLoS One 10, e0130230 (2015), Abstract — Full Text
- Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis: T.H. Yang, et al.; Arthritis. Res. Ther. 17, 364 (2015), Application(s): Measurement of PGE2 in mice serum samples, Abstract — Full Text
- Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation: M.K. McCarthy, et al.; PLoS One 10, e0139235 (2015), Application(s): PGE2 concentration in bronchoalveolar lavage fluid , Abstract — Full Text
- Molecular characterization and knock-down of salmon louse (Lepeophtheirus salmonis) prostaglandin E synthase: C. Eichner, et al.; Exp. Parasitol. 159, 79 (2015), Application(s): ELISA Kit measuring PGE2 levels in salmon lice, Abstract
- Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide: J.Y. Shin, et al.; Int. Immunopharmacol. 29, 730 (2015), Application(s): PGE2 level was measured by ELISA in mice, Abstract
- Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses: A.R. Navratil, et al.; Atherosclerosis 242, 424 (2015), Application(s): ELISA using mouse cell culture supernatant, Abstract
- Insight into the molecular mechanism of an herbal injection by integrating network pharmacology and in vitro: Y.M. Ma, et al.; J. Ethnopharmacol. 173, 91 (2015), Application(s): ELISA using mouse RAW264.7 cells , Abstract
- The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation: A. Ejarque-Ortiz, et al.; PLoS One 10, e0123928 (2015), Application(s): ELISA using mouse microglial supernatant, Abstract — Full Text
- Effectiveness of the combinational treatment of Laminaria japonica and Cistanche tubulosa extracts in hair growth: K. Shin, et al.; Lab. Anim. Res. 31, 24 (2015), Application(s): ELISA using mouse exudate, Abstract — Full Text
- Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells: K. Jung, et al.; PLoS One 10, e0124417 (2015), Application(s): ELISA using human culture supernatant , Abstract — Full Text
- Role of gastric acid inhibition, prostaglandins and endogenous-free thiol groups on the gastroprotective effect of a proteolytic fraction from Vasconcellea cundinamarcensis latex: A. Silva, et al.; J. Pharm. Pharmacol. 67, 133 (2015), Application(s): EIA using rat tissue samples, Abstract — Full Text
- The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma: Y. Yang, et al.; Biomed. Pharmacother. 70, 181 (2015), Application(s): ELISA using human culture medium, Abstract
- Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells: Richter, C., Viergutz, T., et al.; Cytometry A 87, 61 (2015), Abstract
- Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice: J. Shang, et al.; Braz. J. Med. Biol. Res. 47, 1050 (2014), Application(s): Analysis of PGE2 levels in mouse hippocampus tissue, Abstract — Full Text
- Inhibition of COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a chlorogenic acid ester saponin: F. Guan, et al.; Biomed. Rep. 2, 760 (2014), Application(s): Assay of LPS-stimulated RAW264.7 macrophages, Abstract — Full Text
- Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells: J.P. Chou, et al.; PLoS One 9, e99432 (2014), Application(s): EIA using cell culture supernatants, Abstract — Full Text
- Epidermal growth factor and epidermal growth factor signaling attenuate laser-induced melanogenesis: W.J. Yun, et al.; Dermatol. Surg. 39, 1903 (2013), Application(s): HaCaT cell culture supernatant, Abstract
- Transmigration of Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells: M. Díaz-Coránguez, et al.; PLoS One 8, e60655 (2013), Application(s): Quantification was done in 4 day CM derived from rat astrocytes and glioma C6 cells using ELISA, Abstract — Full Text
- Prostaglandin E2 alteration in contraceptive consumers: as a risk factor for inflammatory diseases: M.S. Pour, et al.; Arch. Gynecol. Obstet. 287, 1031 (2013), Application(s): EIA using human serum, Abstract
- Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes: W.Y. Choi, et al.; J. Pharm. Pharmacol. 65, 310 (2013), Application(s): EIA using culture supernatants, Abstract
- Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway: A. Thakur, et al.; J. Transl. Med. 11, 35 (2013), Application(s): EIA using culture supernatants from 3D co-cultures, Abstract — Full Text
- Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity: T. Li, et al.; Med. Oncol. 30, 663 (2013), Application(s): EIA using culture supernatants, Abstract
- Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms: Y. Mao, et al.; Cancer Res. 73, 3877 (2013), Application(s): EIA using culture supernatants, Abstract
- XH-14, a novel danshen methoxybenzo[b]furan derivative, exhibits anti-inflammatory properties in lipopolysaccharide-treated RAW 264.7 cells: G.M. Park, et al.; J. Inflamm. 10, 1 (2013), Application(s): EIA using culture supernatants, Abstract — Full Text
- Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge: J. Kang, et al.; Int. Immunopharmacol. 12, 249 (2012), Application(s): EIA using culture supernatants, Abstract
- Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO: T. Li, et al.; Cancer Lett. 318, 154 (2012), Application(s): EIA using culture supernatants, Abstract
- Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo: H.G. Kim, et al.; Biol. Pharm. Bull. 35, 1287 (2012), Application(s): EIA using culture supernatants, Abstract — Full Text
- Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans: G. Yu, et al.; Am. J. Respir. Crit. Care Med. 186, 752 (2012), Application(s): PGE2 from mice BAL was measured, Abstract
- Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids: W. Stoffel, et al.; EMBO J. 27, 2281 (2008), Application(s): EIA using tissue, Abstract
- Anti-inflammatory effects of isoflavone powder produced from soybean cake: T.H. Kao, et al.; J. Agric. Food Chem. 55, 11068 (2007), Application(s): EIA using peritoneal exudate fluid and peritoneal exudate cell supernatant, Abstract
- Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils: S. Futagami, et al.; Digestion 74, 187 (2006), Abstract
- Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype: H. Reinold, et al.; J. Clin. Invest. 115, 673 (2005), Application(s): PGE2 from the thoracolumbar segment of the spinal cord was measured, mice, Abstract — Full Text
- Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma: M.S. Shaik, et al.; Clin. Cancer Res. 10, 1521 (2004), Application(s): EIA using mouse tissue, Abstract
- Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2: L. Koetzner, et al.; J. Neurosci. 24, 1451 (2004), Application(s): EIA using dialysate, Abstract
- Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells: S. Al-Darmaki, et al.; J. Immunol. 170, 167 (2003), Application(s): EIA using human culture supernatants, Abstract
- Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model: D. Claveau, et al.; J. Immunol. 170, 4738 (2003), Application(s): PGE2 production was determined by enzyme immunoassay analysis using rat tissue, Abstract — Full Text
- Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice: M. Yao, et al.; Cancer Res. 63, 586 (2003), Application(s): Concentration of PGE2 in splenic tumor cystosolic fractions were determined using mouse tissue, Abstract
- The effects of periodontal therapy on intracrevicular prostaglandin E2 concentrations and clinical parameters in pregnancy: F. Yalcin, et al.; J. Periodontol. 73, 173 (2002), Application(s): EIA using gingival crevicular fluid, Abstract
- Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients: G. Almer, et al.; Neurology 58, 1277 (2002), Application(s): EIA using cerebral spinal fluid, Abstract
- Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells: M. Akhtar, et al.; Cancer Res. 61, 2399 (2001), Application(s): EIA using cell culture supernatant, Abstract — Full Text
- Selective cyclooxygenase-2 inhibition by nimesulide in man: L. Cullen, et al.; J. Pharmacol. Exp. Ther. 287, 578 (1998), Application(s): EIA using plasma, Abstract
- Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils: C.G. Maloney, et al.; J. Immunol. 160, 1402 (1998), Application(s): EIA using human cell culture supernatant, Abstract
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