PF-356231

BML-PI155

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MMP inhibitor

Specific non-chelating small-molecule inhibitor of MMP-12 (IC₅₀ = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.

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Product Details

Appearance	Yellow solid.
CAS	766536-21-4
Couple Target	MMP, MMP-12
Couple Type	Inhibitor
Formula	C₂₅H₂₀N₂O₃S
MW	428.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma: Chung, I. C., Chen, L. C., et al.; BMC Cancer 14, 348 (2014), Abstract
MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle apoptosis: H. Williams, et al.; Cardiovasc. Res. 87, 137 (2010), Abstract — Full Text

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PF-356231

BML-PI155

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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