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Perforin 1 (PRF1) is a pore forming cytolytic protein found in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin binds to the target cell’s plasma membrane, and oligomerizes in a Ca2+ dependent manner to form pores on the target cell. The pore formed allows for the passive diffusion of a family of pro-apoptotic proteases, known as the granzymes, into the target cell.
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SDS-PAGE of active human recombinant PRF1
| Regulatory Status |
RUO – Research Use Only |
|---|
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| Alternative Name | Angiotensin-converting enzyme 1, CD143 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in NSO cells. |
| Alternative Name | TACE, A disintegrin and metalloproteinase 17, Tumor necrosis factor-α-converting enzyme |
|---|---|
| Purity | ≥90% (SDS-PAGE) |
| Source | Produced in insect cells. Produced in a baculovirus expression system. |
| Alternative Name | β-Secretase 2, β-Site APP-cleaving enzyme 2, Memapsin-1, ASP-1 |
|---|---|
| Purity | ≥80% (SDS-PAGE) |
| Source | Produced in insect cells. Recombinant soluble BACE2, cloned from human cDNA, secreted as zymogen from insect cells, purified using a C-terminal His-tag, and cleaved to the mature active form. Produced in a baculovirus expression system. |
| Alternative Name | Interleukin 1β converting enzyme, IL-1β converting enzyme, ICE |
|---|---|
| Purity | ≥90% (SDS-PAGE) |
| Source | Produced in E. coli. cDNA encodes residues identical to Asn120-His404 (C-terminus) at Genbank Accession No. M87507, except for an Asp381 to Glu change, introduced to stabilize the enzyme against autoproteolysis. |