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Penitrem A

BML-KC157

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K⁺ channel blocker

Fungal mycotoxin. Selective, irreversible blocker of the smooth muscle high conductance Ca²⁺-activated K⁺ (maxi-K) channel (100% block at 10 nM). Increases spontaneous release of GABA and aspartate from cerebrocortical synaptosomes in rat neuromuscular junction.

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Product Details

Alternative Name	NSC 354845, Tremortin A
Appearance	White solid.
CAS	12627-35-9
Couple Target	Potassium channel
Couple Type	Blocker
Formula	C₃₇H₄₄ClNO₆
MW	634.2
Purity	≥95% (HPLC, TLC)
RTECS	RY7535000
Solubility	Soluble in organic solvents such as methanol, acetone or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ethanol’s interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice: A. Okhuarobo, et al.; Mol. Psychiatry 29, 529 (2024), Abstract
Chlorinated flavonoids modulate the inflammatory process in human blood: C. Proença, et al.; Inflammation. 40, 1155 (2017), Abstract
The cyclooctadepsipeptide anthelmintic emodepside differentially modulates nematode, insect and human calcium-activated potassium (SLO) channel alpha subunits: A. Crisford, et al.; PLoS Negl. Trop. Dis. 9, e0004062 (2015), Abstract — Full Text
SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants: Welz, C., Krüger, N., et al.; PLoS Pathog. 7, e1001330 (2011), Abstract
Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study: P. Breton, et al.; Toxicon 36, 645 (1998), Abstract
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels: H.G. Knaus, et al.; Biochemistry 33, 5819 (1994), Abstract
Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations: B.J. Wilson, et al.; Brain Res. 40, 540 (1972), Abstract

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Penitrem A

BML-KC157

Product Details

Handling & Storage

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